Providing integrated health and social care for older persons: a European overview of issues at stake
نویسنده
چکیده
Telomere length homeostasis is a prerequisite for the generation and growth of cancer. In 485% cancer cells, telomere length is maintained by telomerase that add telomere repeats to the end of telomere DNA. Because the G-rich strand of telomere DNA can fold into G-quadruplex that inhibits telomerase activity, stabilizing telomere quadruplex by small molecules is emerging as a potential therapeutic strategy against cancer. In these applications, the specificity of small molecules toward quadruplex over other forms of DNA is an important property to ensure no processes other than telomere elongation are interrupted. The evaluating assays currently available more or less have difficulty identifying or distinguishing quadruplex-irrelevant effect from quadruplex stabilization. Here, we describe an exonuclease I hydrolysis assay that evaluates quadruplex stabilization by DNA-interacting compounds, discriminates inhibitory effect from different sources and helps determine the optimal compound concentration.
منابع مشابه
Developing integrated health and social care services for older persons in Europe
PURPOSE This paper is to distribute first results of the EU Fifth Framework Project 'Providing integrated health and social care for older persons-issues, problems and solutions' (PROCARE-http://www.euro.centre.org/procare/). The project's first phase was to identify different approaches to integration as well as structural, organisational, economic and social-cultural factors and actors that c...
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INTERLINKS (“Health systems and long-term care for older people in Europe: modelling the interfaces between prevention, rehabilitation, quality of services and informal care”), was a project co-financed by the EU 7th Framework Programme (Grant agreement no. 223037) with a purpose of constructing and validating a framework to describe, analyse and improve long-term care (LTC) systems for older p...
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This paper considers an implication of the idea that proposals for integrated care for older people should start from a focus on the patient, consider co-production solutions to the problems of care fragmentation, and be at a system-wide, cross-organisational level. It follows that the analysis, design and therefore evaluation of integrated care projects should be based upon the journeys which ...
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